Molecular definition of group 1 innate lymphoid cells in the mouse uterus.

ABSTRACT: Determining the function of uterine lymphocytes is challenging because of the dynamic changes in response to sex hormones and, during pregnancy, to the invading foetal trophoblast cells. Here we provide a genome-wide transcriptome atlas of mouse uterine group 1 innate lymphoid cells (ILCs) at mid-gestation. Tissue-resident Eomes⁺CD49a⁺ NK cells (trNK), which resemble human uterine NK cells, are most abundant during early pregnancy, and have gene signatures associated with TGF-β responses and interactions with trophoblast, epithelial, endothelial, smooth muscle cells, leucocytes and extracellular matrix. Conventional NK cells expand late in gestation and may engage in crosstalk with trNK cells involving IL-18 and IFN-γ. Eomes^-CD49a⁺ ILC1s dominate

SUBMITTER: Filipovic I 

PROVIDER: S-EPMC6206068 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature