Activation of Electrophile/Nucleophile Pair by a Nucleophilic and Electrophilic Solvation in a S_NAr Reaction.

ABSTRACT: Nucleophilic aromatic substitution reactions of 4-chloroquinazoline toward aniline and hydrazine were used as a model system to experimentally show that a substrate bearing heteroatoms on the aromatic ring as substituent is able to establish intramolecular hydrogen bond which may be activated by the reaction media and/or the nature of the nucleophile.

SUBMITTER: Sanchez B 

PROVIDER: S-EPMC6206274 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature