Accelerated DNA methylation changes in middle-aged men define sexual dimorphism in human lifespans.

ABSTRACT:

Background

Accelerated age-associated DNA methylation changes in males may explain the earlier onset of age-related diseases (e.g., cardiovascular disease (CVD)) and thus contribute to sexually dimorphic morbidity and lifespan. However, the details regarding the emergence of this sex-biased methylation pattern remain unclear.

Results

To address these issues, we collected publicly available peripheral blood methylation datasets detected by Illumina HumanMethylation450 BeadChip platform from four studies that contain age and gender information of samples. We analyzed peripheral blood methylation data screened from 708 subjects of European ancestry. Results revealed a significant methylation change acceleration in middle-aged males (40-50 years old), which was further supported

SUBMITTER: Xiao FH 

PROVIDER: S-EPMC6206726 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature