Childhood asthma is associated with COPD and known asthma variants in COPDGene: a genome-wide association study.

ABSTRACT:

Background

Childhood asthma is strongly influenced by genetics and is a risk factor for reduced lung function and chronic obstructive pulmonary disease (COPD) in adults. This study investigates self-reported childhood asthma in adult smokers from the COPDGene Study. We hypothesize that childhood asthma is associated with decreased lung function, increased risk for COPD, and that a genome-wide association study (GWAS) will show association with established asthma variants.

Methods

We evaluated current and former smokers ages 45-80 of non-Hispanic white (NHW) or African American (AA) race. Childhood asthma was defined by self-report of asthma, diagnosed by a medical professional, with onset at < 16 years or during childhood. Subjects with a history of childhood asthma were com

SUBMITTER: Hayden LP 

PROVIDER: S-EPMC6206739 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature