MicroRNAs expression profile related with response to preoperative radiochemotherapy in patients with locally advanced gastric cancer.

ABSTRACT:

Background

It is urgent to find some biochemical markers for predicting the radiochemotherapy sensitivity. microRNAs have a huge potential as a predictive biomarker in gastric cancer. The current study aims to identify the microRNAs related to the radiochemotherapy sensitivity in gastric cancer.

Methods

From April 2012 to August 2014, 40 patients with locally advanced gastric cancer were included into the clinical trial in the Fudan University Shanghai Cancer Center. The lesion specimens of 15 patients were obtained by gastroendoscopy before treatment, and the RNA was extracted. microRNAs array was used to identify the microRNAs with different expression level between sensitive group and non-sensitive group. The microRNAs identified in the array were further confirmed by Taq

SUBMITTER: Liu X 

PROVIDER: S-EPMC6206758 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature