Ventilator-induced lung injury is aggravated by antibiotic mediated microbiota depletion in mice.

ABSTRACT:

Background

Antibiotic exposure alters the microbiota, which can impact the inflammatory immune responses. Critically ill patients frequently receive antibiotic treatment and are often subjected to mechanical ventilation, which may induce local and systemic inflammatory responses and development of ventilator-induced lung injury (VILI). The aim of this study was to investigate whether disruption of the microbiota by antibiotic therapy prior to mechanical ventilation affects pulmonary inflammatory responses and thereby the development of VILI.

Methods

Mice underwent 6-8 weeks of enteral antibiotic combination treatment until absence of cultivable bacteria in fecal samples was confirmed. Control mice were housed equally throughout this period. VILI was induced 3 days after comp

SUBMITTER: Wienhold SM 

PROVIDER: S-EPMC6206919 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature