Altered White Matter Diffusivity of the Cingulum Angular Bundle in Posttraumatic Stress Disorder.

ABSTRACT:

Purpose of the study

Prior studies showed posttraumatic stress disorder (PTSD)-related alterations in white matter integrity, but most of these studies have used region-based approaches. We address this limitation by investigating the relationship between PTSD severity and fractional anisotropy (FA) using a tract-based approach.

Procedures

Structural and diffusion magnetic resonance imaging were acquired from 67 combat-exposed US Veterans and processed using FSL/FreeSurfer TRActs Constrained by UnderLying Anatomy. Partial correlations were conducted between PTSD severity and FA of the cingulum and uncinate fasciculi covarying for age, sex, and head motion.

Results

Only FA of the left cingulum angular bundle (CAB) was positively correlated with PTSD symptom severity (<

SUBMITTER: Averill CL 

PROVIDER: S-EPMC6206974 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature