Meta-mining of copy number profiles of high-risk neuroblastoma tumors.

ABSTRACT: Neuroblastoma, a pediatric tumor of the sympathetic nervous system, is predominantly driven by copy number aberrations, which predict survival outcome in global neuroblastoma cohorts and in low-risk cases. For high-risk patients there is still a need for better prognostic biomarkers. Via an international collaboration, we collected copy number profiles of 556 high-risk neuroblastomas generated on different array platforms. This manuscript describes the composition of the dataset, the methods used to process the data, including segmentation and aberration calling, and data validation. t-SNE analysis shows that samples cluster according to MYCN status, and shows a difference between array platforms. 97.3% of samples are characterized by the presence of segmental aberrations, in regions frequ

SUBMITTER: Depuydt P 

PROVIDER: S-EPMC6207068 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature