Consensus on Molecular Subtypes of High-Grade Serous Ovarian Carcinoma.

ABSTRACT: Purpose: The majority of ovarian carcinomas are of high-grade serous histology, which is associated with poor prognosis. Surgery and chemotherapy are the mainstay of treatment, and molecular characterization is necessary to lead the way to targeted therapeutic options. To this end, various computational methods for gene expression-based subtyping of high-grade serous ovarian carcinoma (HGSOC) have been proposed, but their overlap and robustness remain unknown.Experimental Design: We assess three major subtype classifiers by meta-analysis of publicly available expression data, and assess statistical criteria of subtype robustness and classifier concordance. We develop a consensus classifier that represents the subtype classifications of tumors based on the consensus of multipl

SUBMITTER: Chen GM 

PROVIDER: S-EPMC6207081 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature