Effect of Intracoronary Metformin on Myocardial Infarct Size in Swine.

ABSTRACT:

Rationale

Metformin has been demonstrated to decrease infarct size (IS) and prevent postinfarction left ventricular (LV) remodeling in rodents when given intravenously at the time of reperfusion. It remains unclear whether similar cardioprotection can be achieved in a large animal model.

Objective

The objective of this study was to determine whether intravascular infusion of metformin at the time of reperfusion reduces myocardial IS in a porcine model of acute myocardial infarction.

Methods and results

In a blinded and randomized preclinical study, closed-chest swine (n=20) were subjected to a 60-minute left anterior descending coronary artery occlusion to produce myocardial infarction. Contrast-enhanced computed tomography was performed during left anterior descendin

SUBMITTER: Techiryan G 

PROVIDER: S-EPMC6207210 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature