Exposure to Maternal Diabetes Mellitus Causes Renal Dopamine D₁ Receptor Dysfunction and Hypertension in Adult Rat Offspring.

ABSTRACT: Epidemiological and experimental studies suggest that maternal diabetes mellitus programs hypertension that is associated with impaired sodium excretion in the adult offspring. However, the underlying mechanisms are not clear. Because dopamine receptor function is involved in the pathogenesis of hypertension, we hypothesized that impaired renal dopamine D₁ receptor function is also involved in the hypertension in offspring of maternal diabetes mellitus. Maternal diabetes mellitus was induced by a single intraperitoneal injection of streptozotocin (35 mg/kg) to pregnant Sprague-Dawley rats at day 0 of gestation. Compared with the offspring of mothers injected with citrate buffer (control mother offspring), the diabetic mother offspring (DMO) had increased systolic blood pressure

SUBMITTER: Luo H 

PROVIDER: S-EPMC6207228 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature