Serum-derived bovine immunoglobulin for children with diarrhea-predominant irritable bowel syndrome.

ABSTRACT:

Background

Oral serum-derived bovine immunoglobulin (SBI)/protein isolate is a medical food intended to manage chronic diarrhea. It has been shown to improve pain and diarrhea in adults with diarrhea-predominant irritable bowel syndrome (d-IBS).

Aim

To determine if SBI can improve symptoms in children with d-IBS.

Methods

We performed a randomized, double-blind, placebo-controlled, pilot study (NCT02609529) to evaluate the effectiveness of SBI in children 8-18 years with d-IBS. We recorded stool number, abdominal pain, and stool form in all patients for 1 week and then assigned the patients at a ratio of 2:1 to treatment with SBI 5 g BID or placebo for 3 weeks. The patients and their parents completed the Pediatric Quality of Life Inventory™ for Gastrointestinal Sympto

SUBMITTER: Arrouk R 

PROVIDER: S-EPMC6207257 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature