TGFβ, Fibronectin and Integrin α5β1 Promote Invasion in Basal Cell Carcinoma.

ABSTRACT: Basal cell carcinoma (BCC) is the most frequent human cancer and is becoming an important health problem in an aging population. Based on their clinical and histological characteristics, thick BCC are typically divided into low-risk nodular and high-risk infiltrative subtypes, although the underlying mechanisms are poorly understood. We have identified molecular mechanisms that explain the aggressiveness of high-risk infiltrative BCC, with a potential direct clinical impact. In this study, we first show that fibroblasts, transforming growth factor-β, and fibronectin are found preferentially in infiltrative human BCC. This allowed us to develop in vivo models for the study of infiltrative BCC, which in turn let us confirm the role of transforming growth factor-β in inducing peritumoral fibr

SUBMITTER: Kuonen F 

PROVIDER: S-EPMC6207534 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature