Genetic and experimental evidence for the involvement of the CD6 lymphocyte receptor in psoriasis.

ABSTRACT: Psoriasis is a chronic inflammatory skin disease with a strong genetic background and is triggered by environmental factors. Available evidence supports CD6, a lymphocyte surface receptor mostly expressed by T cells, as a putative target in autoimmunity. Accordingly, a humanized anti-CD6 antibody has been assayed for the treatment of certain autoimmune disorders, including psoriasis. Here, we present novel evidence in mice and humans for a direct involvement of CD6 in psoriasis pathophysiology. First, an attenuated form of imiquimod-induced psoriasis-like skin inflammation was demonstrated in CD6-deficient mice, as deduced from lower epidermal thickness and local reduced production of pro-inflammatory cytokines, namely, interleukin-17A. Thus, isolated CD4⁺CD62L⁺ T cel

SUBMITTER: Consuegra-Fernandez M 

PROVIDER: S-EPMC6207571 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature