Cellular Response to Surface Morphology: Electrospinning and Computational Modeling.

ABSTRACT: Surface properties of biomaterials, such as chemistry and morphology, have a major role in modulating cellular behavior and therefore impact on the development of high-performance devices for biomedical applications, such as scaffolds for tissue engineering and systems for drug delivery. Opportunely-designed micro- and nanostructures provides a unique way of controlling cell-biomaterial interaction. This mini-review discusses the current research on the use of electrospinning (extrusion of polymer nanofibers upon the application of an electric field) as effective technique to fabricate patterns of micro- and nano-scale resolution, and the corresponding biological studies. The focus is on the effect of morphological cues, including fiber alignment, porosity and surface roughness of electros

SUBMITTER: Denchai A 

PROVIDER: S-EPMC6207584 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature