The GbsR Family of Transcriptional Regulators: Functional Characterization of the OpuAR Repressor.

ABSTRACT: Accumulation of compatible solutes is a common stress response of microorganisms challenged by high osmolarity; it can be achieved either through synthesis or import. These processes have been intensively studied in Bacillus subtilis, where systems for the production of the compatible solutes proline and glycine betaine have been identified, and in which five transporters for osmostress protectants (Opu) have been characterized. Glycine betaine synthesis relies on the import of choline via the substrate-restricted OpuB system and the promiscuous OpuC transporter and its subsequent oxidation by the GbsAB enzymes. Transcription of the opuB and gbsAB operons is under control of the MarR-type regulator GbsR, which acts as an intracellular choline-responsive repressor. Mode

SUBMITTER: Ronzheimer S 

PROVIDER: S-EPMC6207618 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature