NF-κB p65 directs sex-specific neuroprotection in human neurons.

ABSTRACT: Protection of neurons against oxidative stress is crucial during neuronal development, maintenance and for treating neurodegenerative diseases. However, little is known about the molecular mechanisms underlying sex-specific maturation and survival of neurons. In the present study, we demonstrate NF-κB-p65 mediated neuroprotection in human glutamatergic neurons differentiated from inferior turbinate stem cells (ITSCs) in a sex-dependent manner. We successfully differentiated ITSCs into MAP-2⁺/NF200⁺/Synaptophysin⁺/vGlut2⁺-glutamatergic neurons in vitro and ex vivo and validated their functionality. TNF-α-dependent NF-κB-p65 activation was accompanied by significant neuroprotection against oxidative stress-induced neuronal death, which was surprisi

SUBMITTER: Ruiz-Perera LM 

PROVIDER: S-EPMC6207661 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature