The c-Jun and JunB transcription factors facilitate the transit of classical Hodgkin lymphoma tumour cells through G₁.

ABSTRACT: Classical Hodgkin Lymphoma (cHL) is primarily a B cell lymphoid neoplasm and a member of the CD30-positive lymphomas. cHL and the other CD30-positive lymphomas are characterized by the elevated expression and/or constitutive activation of the activator protein-1 (AP-1) family transcription factors, c-Jun and JunB; however, the specific roles they play in the pathobiology of cHL are unclear. In this report we show that reducing either c-Jun or JunB expression with short-hairpin RNAs (shRNAs) reduced the growth of cHL cell lines in vitro and in vivo, primarily through impairing cell cycle transition through G₁. We further investigated the effect of c-Jun and JunB knock-down on proliferation in another CD30-positive lymphoma, anaplastic lymphoma kinase-positive, anaplastic large ce

SUBMITTER: Zhang J 

PROVIDER: S-EPMC6207696 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature