Ion channels in EEG: isolating channel dysfunction in NMDA receptor antibody encephalitis.

ABSTRACT: See Roberts and Breakspear (doi:10.1093/brain/awy136) for a scientific commentary on this article.Neurological and psychiatric practice frequently lack diagnostic probes that can assess mechanisms of neuronal communication non-invasively in humans. In N-methyl-d-aspartate (NMDA) receptor antibody encephalitis, functional molecular assays are particularly important given the presence of NMDA antibodies in healthy populations, the multifarious symptomology and the lack of radiological signs. Recent advances in biophysical modelling techniques suggest that inferring cellular-level properties of neural circuits from macroscopic measures of brain activity is possible. Here, we estimated receptor function from EEG in patients with NMDA receptor antibody encephalitis (n = 29) as well as from ence

SUBMITTER: Symmonds M 

PROVIDER: S-EPMC6207885 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature