Non-syndromic Cleft Lip and Palate Polymorphisms Affect Normal Lip Morphology.

ABSTRACT: Non-syndromic cleft lip with or without palate (NSCL/P) is a frequent malformation of the facial region. Genetic variants (SNPs) within nineteen loci have been previously associated with NSCL/P in GWAS studies of European individuals. These common variant SNPs may have subtler effects on the morphology of the lip and face in unaffected individuals. Several studies have investigated the genetic influences on facial morphology using land-marking methods, but these landmarks are sparse in the lip region. The aim of this study is to assess for associations between the nineteen NSCL/P SNPs and normal lip phenotypes, using a detailed categorical scale. Three-dimensional laser scanned facial images were obtained of 4,747 subjects recruited from the Avon Longitudinal Study of Parents and Children

SUBMITTER: Wilson-Nagrani C 

PROVIDER: S-EPMC6207999 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature