Genetic sequence characterization and naturally acquired immune response to Plasmodium vivax Rhoptry Neck Protein 2 (PvRON2).

ABSTRACT:

Background

The genetic diversity of malaria antigens often results in allele variant-specific immunity, imposing a great challenge to vaccine development. Rhoptry Neck Protein 2 (PvRON2) is a blood-stage antigen that plays a key role during the erythrocyte invasion of Plasmodium vivax. This study investigates the genetic diversity of PvRON2 and the naturally acquired immune response to P. vivax isolates.

Results

Here, the genetic diversity of PvRON2_1828-2080 and the naturally acquired humoral immune response against PvRON2_1828-2080 in infected and non-infected individuals from a vivax malaria endemic area in Brazil was reported. The diversity analysis of PvRON2_1828-2080 revealed that the protein is conserved in isolates in Brazil and worldwid

SUBMITTER: Bittencourt NC 

PROVIDER: S-EPMC6208078 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature