APC gene is modulated by hsa-miR-135b-5p in both diffuse and intestinal gastric cancer subtypes.

ABSTRACT:

Background

Several genetic and epigenetic alterations are related to the development and progression of Gastric Cancer (GC), one of those being the deregulated microRNA (miRNA) expression profile. miRNAs are small noncoding RNAs that negatively regulate the expression of thousands of genes, including oncogenes and tumor suppressor genes. Our group identified, in previous studies, some miRNAs that are differentially expressed in GC when compared to the gastric mucosa without cancer, including hsa-miR-29c and hsa-miR-135b. The aim of the study was to modulate the expression of the miRNAs hsa-miR-29c-5p and hsa-miR-135b-5p and evaluate the expression of their target genes in 2D and 3D cell cultures.

Methods

hsa-miR-29c-5p and hsa-miR-135b-5p expression profiles were modulated b

SUBMITTER: Magalhaes L 

PROVIDER: S-EPMC6208123 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature