Propofol-induced unresponsiveness is associated with impaired feedforward connectivity in cortical hierarchy.

ABSTRACT:

Background

Impaired consciousness has been associated with impaired cortical signal propagation after transcranial magnetic stimulation (TMS). We hypothesised that the reduced current propagation under propofol-induced unresponsiveness is associated with changes in both feedforward and feedback connectivity across the cortical hierarchy.

Methods

Eight subjects underwent left occipital TMS coupled with high-density EEG recordings during wakefulness and propofol-induced unconsciousness. Spectral analysis was applied to responses recorded from sensors overlying six hierarchical cortical sources involved in visual processing. Dynamic causal modelling (DCM) of induced time-frequency responses and evoked response potentials were used to investigate propofol's effects on connectivi

SUBMITTER: Sanders RD 

PROVIDER: S-EPMC6208295 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature