Corticohippocampal Dysfunction In The OBiden Mouse Model Of Primary Oligodendrogliopathy.

ABSTRACT: Despite concerted efforts over decades, the etiology of multiple sclerosis (MS) remains unclear. Autoimmunity, environmental-challenges, molecular mimicry and viral hypotheses have proven equivocal because early-stage disease is typically presymptomatic. Indeed, most animal models of MS also lack defined etiologies. We have developed a novel adult-onset oligodendrogliopathy using a delineated metabolic stress etiology in myelinating cells, and our central question is, "how much of the pathobiology of MS can be recapitulated in this model?" The analyses described herein demonstrate that innate immune activation, glial scarring, cortical and hippocampal damage with accompanying electrophysiological, behavioral and memory deficits naturally emerge from disease progression. Molecular analyses

SUBMITTER: Radecki DZ 

PROVIDER: S-EPMC6208344 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature