Oxytetracycline have the therapeutic efficiency in CD133⁺ HCC population through suppression CD133 expression by decreasing of protein stability of CD133.

ABSTRACT: Cancer stem cells (CSCs) are considered a serious sub-population in cancer tissues because of their strong resistance to conventional chemotherapy and radiotherapy. Thus, the current advancements in the use of liver cancer stem cells (LCSC) to develop efficient and organized means to an antitumor agent is quickly gaining recognition as a novel goal. Previously, we characterized CSCs in primary hepatocellular carcinoma (HCC) and identified CD133 as a CSC cell-surface marker. In this study, we proposed to use non-target based high throughput screening (HTS) approach to specifically target AFP⁺/CD133⁺ HCC present in mixed populations of HCC cells with hepatocytes. Through screening, we identified oxytetracycline, which showed significant inhibition activity of LCSC popul

SUBMITTER: Song Y 

PROVIDER: S-EPMC6208387 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature