Targeting Adults for Supplementary Immunization Activities of Measles Control in Central China: A Mathematical Modelling Study.

ABSTRACT: Routine immunizations and supplementary immunization activities (SIAs) have significantly improved measles control over the past two decades in China. Progress towards eliminating measles currently faces multiple challenges as the infection age increases, and adult-targeted SIA strategies are being considered. This study developed an age-stratified susceptible-exposed-infectious-recovered model using a recently published contact matrix to depict measles transmissions between individuals in seven age groups. Hubei, a high measles-incidence province in central China, was the selected setting. The baseline scenario was calibrated by fitting with the 2012-2015 age-stratified incidence data. SIAs targeting multiple age groups were simulated. Adult-targeted (>29 years) two-year SIA cycles produc

SUBMITTER: Chong KC 

PROVIDER: S-EPMC6208397 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature