Augmented liver inflammation in a microsomal prostaglandin E synthase 1 (mPGES-1)-deficient diet-induced mouse NASH model.

ABSTRACT: In a subset of patients, non-alcoholic fatty liver disease (NAFLD) is complicated by cell death and inflammation resulting in non-alcoholic steatohepatitis (NASH), which may progress to fibrosis and subsequent organ failure. Apart from cytokines, prostaglandins, in particular prostaglandin E₂ (PGE₂), play a pivotal role during inflammatory processes. Expression of the key enzymes of PGE₂ synthesis, cyclooxygenase 2 and microsomal PGE synthase 1 (mPGES-1), was increased in human NASH livers in comparison to controls and correlated with the NASH activity score. Both enzymes were also induced in NASH-diet-fed wild-type mice, resulting in an increase in hepatic PGE₂ concentration that was completely abrogated in mPGES-1-deficient mice. PGE₂

SUBMITTER: Henkel J 

PROVIDER: S-EPMC6208405 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature