Levels of Par-1 kinase determine the localization of Bruchpilot at the Drosophila neuromuscular junction synapses.

ABSTRACT: Functional synaptic networks are compromised in many neurodevelopmental and neurodegenerative diseases. While the mechanisms of axonal transport and localization of synaptic vesicles and mitochondria are relatively well studied, little is known about the mechanisms that regulate the localization of proteins that localize to active zones. Recent finding suggests that mechanisms involved in transporting proteins destined to active zones are distinct from those that transport synaptic vesicles or mitochondria. Here we report that localization of BRP-an essential active zone scaffolding protein in Drosophila, depends on the precise balance of neuronal Par-1 kinase. Disruption of Par-1 levels leads to excess accumulation of BRP in axons at the expense of BRP at active zones. Temporal analyses d

SUBMITTER: Barber KR 

PROVIDER: S-EPMC6208417 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature