Surgical margin status and its impact on prostate cancer prognosis after radical prostatectomy: a meta-analysis.

ABSTRACT: BACKGROUND AND PURPOSE:Positive surgical margins (PSMs) correlate with adverse outcomes in numerous solid tumours. However, the prognostic value of PSMs in prostate cancer (PCa) patients who underwent radical prostatectomy remains unclear. Herein, we performed a meta-analysis to evaluate the association between PSMs and the prognostic value for biochemical recurrence-free survival (BRFS), cancer-specific survival (CSS), overall survival (OS), cancer-specific mortality (CSM) and overall mortality (OM) in PCa patients. MATERIALS AND METHODS:According to the PRISMA statement, online databases PubMed, EMBASE and Web of Science were searched to identify relevant studies published prior to February 2018. The hazard ratios (HRs) and 95% confidence intervals (95% CIs) were calculated to evaluate t

SUBMITTER: Zhang L 

PROVIDER: S-EPMC6208659 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature