Lessons from a systematic literature review of the effectiveness of recombinant factor VIIa in acquired haemophilia.

ABSTRACT: To conduct a systematic review of the literature reporting efficacy and safety of recombinant factor VIIa (rFVIIa) for the treatment of bleeding in acquired haemophilia and, if data permitted, undertake a meta-analysis of the current evidence. MEDLINE^®, Embase^®, and the Cochrane Central Register of Controlled Trials (CENTRAL) databases were searched for all studies on rFVIIa treatment in acquired haemophilia. Heterogeneity of included studies was measured using the inconsistency index (I²). Of the 2353 publications screened, 290 potentially relevant references were identified: 12 studies published in 32 publications met inclusion criteria. In total, 1244 patients and 1714 bleeds were included (671 patients received rFVIIa treatment for 1063 bleeds). In seve

SUBMITTER: Tiede A 

PROVIDER: S-EPMC6208690 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature