Opposite development of short- and long-range anterior cingulate pathways in autism.

ABSTRACT: Autism has been linked with the changes in brain connectivity that disrupt neural communication, especially involving frontal networks. Pathological changes in white matter are evident in adults with autism, particularly affecting axons below the anterior cingulate cortices (ACC). It is still unknown whether axon pathology appears early or late in development and whether it changes or not from childhood through adulthood. To address these questions, we examined typical and pathological development of about 1 million axons in post-mortem brains of children, adolescents, and adults with and without autism (ages 3-67 years). We used high-resolution microscopy to systematically sample and study quantitatively the fine structure of myelinated axons in the white matter below ACC. We provide nove

SUBMITTER: Zikopoulos B 

PROVIDER: S-EPMC6208731 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature