Radiomics analysis of pre-treatment [¹⁸F]FDG PET/CT for patients with metastatic colorectal cancer undergoing palliative systemic treatment.

ABSTRACT:

Background

The aim of this study was to assess radiomics features on pre-treatment [¹⁸F]FDG positron emission tomography (PET) as potential biomarkers for response and survival in patients with metastatic colorectal cancer (mCRC).

Methods

Patients with mCRC underwent [¹⁸F]FDG PET/computed tomography (CT) prior to first- or third-line palliative systemic treatment. Tumour lesions were semiautomatically delineated and standard uptake value (SUV), metabolically active tumour volume (MATV), total lesion glycolysis (TLG), entropy, area under the curve of the cumulative SUV-volume histogram (AUC-CSH), compactness and sphericity were obtained.

Results

Lesions of 47 patients receiving third-line systemic treatment had higher SUV_max, SUV_pe

SUBMITTER: van Helden EJ 

PROVIDER: S-EPMC6208805 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature