Distinct [¹⁸F]THK5351 binding patterns in primary progressive aphasia variants.

ABSTRACT:

Purpose

To assess the binding of the PET tracer [¹⁸F]THK5351 in patients with different primary progressive aphasia (PPA) variants and its correlation with clinical deficits. The majority of patients with nonfluent variant (NFV) and logopenic variant (LV) PPA have underlying tauopathy of the frontotemporal lobar or Alzheimer disease type, respectively, while patients with the semantic variant (SV) have predominantly transactive response DNA binding protein 43-kDa pathology.

Methods

The study included 20 PPA patients consecutively recruited through a memory clinic (12 NFV, 5 SV, 3 LV), and 20 healthy controls. All participants received an extensive neurolinguistic assessment, magnetic resonance imaging and amyloid biomarker tests. [¹⁸F]THK5351 binding pa

SUBMITTER: Schaeverbeke J 

PROVIDER: S-EPMC6208807 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature