Robust Findings From 25 Years of PTSD Genetics Research.

ABSTRACT:

Purpose of review

The purpose of this review is to contextualize findings from the first 25 years of PTSD genetics research, focusing on the most robust findings and interpreting results in light of principles that have emerged from modern genetics studies.

Recent findings

Genome-wide association studies (GWAS) encompassing tens of thousands of participants enabled the first molecular genetic heritability and genetic correlation estimates for PTSD in 2017. In 2018, highly promising loci for PTSD were reported, including variants in and near the CAMKV, KANSL1, and TCF4 genes. Twin studies from 25 years ago established that PTSD is genetically influenced and foreshadowed the molecular genetic findings of today. Discoveries that were impossible with smaller studies have been ac

SUBMITTER: Duncan LE 

PROVIDER: S-EPMC6209025 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature