Abnormal Morphology of Select Cortical and Subcortical Regions in Neurofibromatosis Type 1.

ABSTRACT: Purpose To evaluate whether patients with neurofibromatosis type 1 (NF1)-a multisystem neurodevelopmental disorder with myriad imaging manifestations, including focal transient myelin vacuolization within the deep gray nuclei, brainstem, and cerebellum-exhibit differences in cortical and subcortical structures, particularly in subcortical regions where these abnormalities manifest. Materials and Methods In this retrospective study, by using clinically obtained three-dimensional T1-weighted MR images and established image analysis methods, 10 intracranial volume-corrected subcortical and 34 cortical regions of interest (ROIs) were quantitatively assessed in 32 patients with NF1 and 245 age- and sex-matched healthy control subjects. By using linear models, ROI cortical thicknesses and volume

SUBMITTER: Barkovich MJ 

PROVIDER: S-EPMC6209062 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature