Endothelial FN (Fibronectin) Deposition by α5β1 Integrins Drives Atherogenic Inflammation.

ABSTRACT: Objective- Alterations in extracellular matrix quantity and composition contribute to atherosclerosis, with remodeling of the subendothelial basement membrane to an FN (fibronectin)-rich matrix preceding lesion development. Endothelial cell interactions with FN prime inflammatory responses to a variety of atherogenic stimuli; however, the mechanisms regulating early atherogenic FN accumulation remain unknown. We previously demonstrated that oxLDL (oxidized low-density lipoprotein) promotes endothelial proinflammatory gene expression by activating the integrin α5β1, a classic mediator of FN fibrillogenesis. Approach and Results- We now show that oxLDL drives robust endothelial FN deposition and inhibiting α5β1 (blocking antibodies, α5 knockout cells) completely inhibits oxLDL-induced FN dep

SUBMITTER: Al-Yafeai Z 

PROVIDER: S-EPMC6209122 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature