Performance testing protocol for closed-system transfer devices used during pharmacy compounding and administration of hazardous drugs.

ABSTRACT:

Objectives

The United States National Institute for Occupational Safety and Health (NIOSH) is developing a protocol to assess the containment performance of closed system transfer devices (CSTDs) when used for drug preparation (task 1) and administration (task 2) and published a draft protocol in September 2016. Nine possible surrogates were proposed by NIOSH for use in the testing. The objectives of this study were to: (A) select the most appropriate surrogate; (B) validate the NIOSH protocol using this surrogate; and (C) determine the containment performance of four commercial CSTDs as compared with an open system of needle and syringe using the validated NIOSH protocol.

Methods

2-Phenoxyethanol (2-POE) was selected as a surrogate based on its water solubility, Henry's vol

SUBMITTER: Wilkinson AS 

PROVIDER: S-EPMC6209153 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature