Chiral Assembly Preferences and Directing Effects in Supramolecular Two-Component Organogels.

ABSTRACT: The impact of chirality on the self-assembly of supramolecular gels is of considerable importance, as molecular-scale programming can be translated into nanostructuring and ultimately affect macroscopic performance. This paper explores the effect of chirality on the assembly of two-component gels comprised of a second-generation dendritic lysine peptide acid, containing three chiral centres, and an amine. This combination forms an acid⁻amine complex that assembles into nanofibres through peptide-peptide hydrogen bonds, leading to organogels. With achiral amines, a racemic mixture of l,l,l and d,d,d dendritic peptide acids surprisingly forms the best gels-more commonly, mixing enantiomers suppresses gelation. Thermodynamic studies demonstrate that depending on the amine, the greater stabili

SUBMITTER: Edwards W 

PROVIDER: S-EPMC6209267 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature