Characterization of Solubilizing Nanoaggregates Present in Different Versions of Simulated Intestinal Fluid.

ABSTRACT: The absorption of hydrophobic drugs and nutrients from the intestine is principally determined by the amount that can be dissolved by the endogenous fluids present in the gut. Human intestinal fluids (HIFs) comprise a complex mixture of bile salts, phospholipids, steroids and glycerides that vary in composition in the fed and fasted state and between subjects. A number of simulated intestinal fluid (SIF) compositions have been developed to mimic fasted and fed state intestinal conditions and allow the in vitro determination of drug solubility as a proxy for the maximum dissolved concentration it is possible to reach. In particular these solvents are used during the development of lipophilic and poorly water-soluble drugs but questions remain around the differences that may arise from the s

SUBMITTER: Clulow AJ 

PROVIDER: S-EPMC6209315 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature