Histoplasma capsulatum antigen detection tests as an essential diagnostic tool for patients with advanced HIV disease in low and middle income countries: A systematic review of diagnostic accuracy studies.

ABSTRACT:

Introduction

Disseminated histoplasmosis, a disease that often resembles and is mistaken for tuberculosis, is a major cause of death in patients with advanced HIV disease. Histoplasma antigen detection tests are an important addition to the diagnostic arsenal for patients with advanced HIV disease and should be considered for inclusion on the World Health Organization Essential Diagnostics List.

Objective

Our objective was to systematically review the literature to evaluate the diagnostic accuracy of Histoplasma antigen tests in the context of advanced HIV disease, with a focus on low- and middle-income countries.

Methods

A systematic review of the published literature extracted data on comparator groups, type of histoplasmosis, HIV status, performance results, patien

SUBMITTER: Nacher M 

PROVIDER: S-EPMC6209380 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature