Ontology highlight
ABSTRACT:
SUBMITTER: Suryawanshi H
PROVIDER: S-EPMC6209386 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Suryawanshi Hemant H Morozov Pavel P Straus Alexander A Sahasrabudhe Nicole N Max Klaas E A KEA Garzia Aitor A Kustagi Manjunath M Tuschl Thomas T Williams Zev Z
Science advances 20181031 10
The placenta and decidua interact dynamically to enable embryonic and fetal development. Here, we report single-cell RNA sequencing of 14,341 and 6754 cells from first-trimester human placental villous and decidual tissues, respectively. Bioinformatic analysis identified major cell types, many known and some subtypes previously unknown in placental villi and decidual context. Further detailed analysis revealed proliferating subpopulations, enrichment of cell type-specific transcription factors, ...[more]