High-throughput screening for selective appetite modulators: A multibehavioral and translational drug discovery strategy.

ABSTRACT: How appetite is modulated by physiological, contextual, or pharmacological influence is still unclear. Specifically, the discovery of appetite modulators is compromised by the abundance of side effects that usually limit in vivo drug action. We set out to identify neuroactive drugs that trigger only their intended single behavioral change, which would provide great therapeutic advantages. To identify these ideal bioactive small molecules, we quantified the impact of more than 10,000 compounds on an extended series of different larval zebrafish behaviors using an in vivo imaging strategy. Known appetite-modulating drugs altered feeding and a pleiotropy of behaviors. Using this multibehavioral strategy as an active filter for behavioral side effects, we identified previously unidentified com

SUBMITTER: Jordi J 

PROVIDER: S-EPMC6209392 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature