Association between the polymorphisms of CALM1 gene and osteoarthritis risk: a meta-analysis based on observational studies.

ABSTRACT: The existing studies on the association between polymorphisms of Calmodulin 1 (CALM1) gene and the risk of osteoarthritis (OA, a complex multifactorial disease and a major degenerative form of arthritis) in different populations have yielded conflicting findings. Therefore, we conducted a meta-analysis by systematically searching PubMed, Embase, Medline, Cochrane Library and Google Scholar, and assessing this association by calculating pooled odds ratios with 95% confidence intervals. Subgroup analyses stratified by ethnicity, OA type, and genotype were also conducted. Six studies (2752 cases and 3259 controls) involving six single nucleotide polymorphisms were included. Our data suggested that the T allele and genotype TT of the rs12885713 polymorphism, and the C allele of t

SUBMITTER: Yang H 

PROVIDER: S-EPMC6209589 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature