Epigenetic Control of Endocrine Pancreas Differentiation in vitro: Current Knowledge and Future Perspectives.

ABSTRACT: The raising worldwide prevalence of Type 1 and Type 2 diabetes mellitus (T1DM and T2DM) solicits the derivation of in vitro methods yielding mature and fully functional β-cells to be used in regenerative medicine. Several protocols to differentiate human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) into human pancreatic β-like cells have recently been developed. These methods, coupled with a bioengineering approach using biocompatible encapsulating devices, have recently led to experimental clinical trials showing great promises to ultimately end the battle of diabetic patients for managing hyperglycemia. However, in vitro differentiation protocols face the challenge of achieving homogenous population of mono-hormonal insulin-secreting mature β-cell

SUBMITTER: Astro V 

PROVIDER: S-EPMC6209628 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature