The Occurence of Colistin-Resistant Hypervirulent Klebsiella pneumoniae in China.

ABSTRACT: Hypervirulent Klebsiella pneumoniae strains are usually susceptible to many antimicrobial agents including colistin. Here we report the isolation and characterization of several colistin-resistant hypervirulent K. pneumoniae clinical strains. K. pneumoniae strains recovered from blood samples were collected at a university hospital in China. MICs of colistin were determined using microdilution. Colistin-resistant strains were subjected to whole genome sequencing to reveal their clonal background, antimicrobial resistance determinants and virulence factors. Virulence assays were performed with strains carrying the mucoid phenotype regulator gene rmpA using wax moth larvae. The pmrB gene encoding a P344L substitution was cloned into a colistin-susceptible <

SUBMITTER: Lu Y 

PROVIDER: S-EPMC6209640 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature