A Comprehensive Analysis of the Association Between SNCA Polymorphisms and the Risk of Parkinson's Disease.

ABSTRACT: Background: Various studies have reported associations between synuclein alpha (SNCA) polymorphisms and Parkinson's disease (PD) risk. However, the results are inconsistent. We conducted a comprehensive meta-analysis of the associations between SNCA single-nucleotide polymorphisms (SNPs) and PD risk in overall populations and subpopulations by ethnicity. Methods: Standard meta-analysis was conducted according to our protocol with a cutoff point of p < 0.05. To find the most relevant SNCA SNPs, we used a cutoff point of p < 1 × 10^-5 in an analysis based on the allele model. In the subgroup analysis by ethnicity, we divided the overall populations into five ethnic groups. We conducted further analysis on the most relevant SNPs using

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC6209653 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature