Exploring Exercise- and Context-Induced Peptide Changes in Mice by Quantitative Mass Spectrometry.

ABSTRACT: Recent research suggests that exercise may help facilitate abstinence from cocaine addiction, though the mechanisms are not well understood. In mice, wheel running accelerates the extinction of conditioned place preference (CPP) for cocaine, providing an animal model for evaluating potential neurological mechanisms. The objective of this study was to quantify dynamic changes in endogenous peptides in the amygdala and dentate gyrus of the hippocampus in mice exposed to a context paired with the effects of cocaine, and in response to exercise. Male C57BL/6J mice conditioned to cocaine were housed with or without running wheels for 30 days. Following a CPP test and final exposure to either a cocaine- or saline-associated context, peptides were measured in brain tissue extracts using label-fre

SUBMITTER: Dowd SE 

PROVIDER: S-EPMC6210063 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature