Protein Palmitoylation Plays an Important Role in Trichomonas vaginalis Adherence.

ABSTRACT: The flagellated protozoan parasite Trichomonas vaginalis is the etiologic agent of trichomoniasis, the most common non-viral sexually transmitted infection worldwide. As an obligate extracellular pathogen, adherence to epithelial cells is critical for parasite survival within the human host and a better understanding of this process is a prerequisite for the development of therapies to combat infection. In this sense, recent work has shown S-acylation as a key modification that regulates pathogenesis in different protozoan parasites. However, there are no reports indicating whether this post-translational modification is a mechanism operating in T. vaginalis In order to study the extent and function of S-acylation in T. vaginalis biology, we undertook a proteomic study

SUBMITTER: Nievas YR 

PROVIDER: S-EPMC6210223 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature