Association Between STAT4 rs7574865 Polymorphism and Rheumatoid Arthritis: Debate Unresolved.

ABSTRACT:

Background

STAT4 rs7574865 polymorphism has been evidently associated with susceptibility to Rheumatoid Arthritis (RA) in European and Eastern Asian populations, whereas studies in other countries reported otherwise.

Objective

We investigated the distribution of STAT4 rs7574865 polymorphism in a group of Syrian RA patients.

Methods

Eighty-one RA patients and forty healthy controls were enrolled and STAT4 rs7574865 was genotyped by direct sequencing. RA patients were stratified according to Anti-Citrullinated Protein Antibodies (ACPA) status for analysis.

Results

Minor T allele frequencies were 30.4%, 16.7%, and 23.8% in ACPA-positive RA patients, ACPA-negative RA patients, and healthy controls, respectively. No significant differences in

SUBMITTER: Tarakji I 

PROVIDER: S-EPMC6210524 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature