Extrahepatic PPARα modulates fatty acid oxidation and attenuates fasting-induced hepatosteatosis in mice.

ABSTRACT: PPARα (PPARA), expressed in most oxidative tissues, is a major regulator of lipid homeostasis; hepatic PPARA plays a critical role during the adaptive fasting response by promoting FA oxidation (FAO). To clarify whether extrahepatic PPARA activity can protect against lipid overload when hepatic PPARA is impaired, lipid accumulation was compared in WT (Ppara^+/+), total body Ppara-null (Ppara^-/-), and hepatocyte-specific Ppara-null (Ppara^ΔHep) mice that were fasted for 24 h. Histologic staining indicated reduced lipid accumulation in Ppara^ΔHep versus Ppara^-/- mice, and biochemical analyses revealed diminished medium- and long-chain FA accumulation in Ppara^ΔHep mouse liver

SUBMITTER: Brocker CN 

PROVIDER: S-EPMC6210912 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature